Table 1.

FBDD programs with respective approaches.

Program	Algorithm	FBDD Approach	SA
AUTOGROW	Docking + Genetic Algorithm	Growing	YES (Latest version)
LUDI	Empirical scoring	Linking	NO
AUTO T and T	Transplants fragments into the lead	Merging	NO
LeadOp+R	Looks for associated reaction rules	Growing	YES
GANDI	Genetic Algorithm	Linking	NO
LigBuilder 2	Genetic Algorithm	Linking and Growing	YES
ADAPT	Genetic Algorithm	Growing	NO