Table 3.

Experimental data for the five most potent MTH1 inhibitors (data taken from Rudling et al., 2017).

Fragment ID	Fragment 2D structure	Fragment IC50	Most potent analog 2D structure	Analog IC50
7		79 μM		0.17 μM
8		24 μM		3.5 μM
9		26 μM	n/a	n/a
10		23 μM		0.12 μM
11		5.6 μM	n/a	n/a

n/a, not available.