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. 2020 Feb 24;10:3233. doi: 10.1038/s41598-020-59997-y

Figure 2.

Figure 2

miR-34a depletion alleviates tight junction disruption following murine experimental stroke. Immunohistochemical staining of coronal cryosections of ischemic brains from WT and miR-34a−/− mice following 1 h tMCAO and 6 h reperfusion. (A) Representative images for Occludin immunoreactivity detected in both contralateral and ipsilateral hemispheres including cortex and striatum area. Scale bar = 100 µm. Quantification of Occludin (B), ZO-1 (C), and Claudin-5 (D). ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, n = 5 per group, and one-way ANOVA followed by post hoc Tukey’s test was used for data analyses.