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. 2020 Feb 24;10:3294. doi: 10.1038/s41598-020-60319-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PBD-C06 sequences of VL and VH chains. Amino acid sequence including CDRs (grey), de-immunized amino acids (red) and substitutions for protein stability (yellow). D/I represents the de-immunized sequence of PBD-C06 and H and M are the human IGHV1-3*01 and murine hybridoma precursor sequences, respectively. Boxes indicate two framework regions potentially involved in antigen recognition.