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. 2020 Feb 18;11:233. doi: 10.3389/fimmu.2020.00233

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Copyright © 2020 Geng, Tang, Wang, Sun, Wang, Tsao, Feng and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-6 is a direct target of let-7f. (A) Construction of TGF-β1'-UTR luciferase vector. (B) IL-6 response element reporter assay with let-7f precursor or let-7f inhibitors. IL-6 3′-UTR is involved in let-7f regulated gene expression. (C,D) The effect of let-7f and IL-6 on AKT, p38, ERK, MAPK, and STAT3 pathway in BM-MSCs. (E,F) The role of AKT inhibitor (GSK690693), p38/MAPK inhibitor (SB203580), and STAT3 inhi bitor (NSC74859) in immunoregulatory effect of let-7f related oligonucleotide transfected BM-MSCs on Treg and Th17 cells. All data are mean ± SEM. n = 6, *P < 0.05, **P < 0.01.