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. 2020 Feb 18;11:223. doi: 10.3389/fimmu.2020.00223

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Copyright © 2020 Zemek, Chin, Nowak, Millward, Lake and Lesterhuis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A personalized pre-treatment strategy to optimize outcomes to immune checkpoint blockade. We propose a pre-treatment approach to treating cancer patients, where tumors displaying features of a non-responsive TME can be first sensitized to attain a favorable TME, to improve chances of response to immune checkpoint blockade. Figures made in ^©BioRender-biorender.com. Adapted from a figure we published recently in Science Translational Medicine (7).