Table 4.
Multivariable Cox models for metastasis breast cancer patients in surgery and non–surgery set.
| Variables | OS | BCSS | ||||||
|---|---|---|---|---|---|---|---|---|
| No surgery | Surgery | No surgery | Surgery | |||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| <35 | Reference | Reference | Reference | Reference | ||||
| 35–49 | 1.02 (0.78–1.33) | 0.888 | 1.24 (0.89–1.75) | 0.221 | 1.03 (0.78–1.36) | 0.817 | 1.35 (0.94–1.92) | 0.100 |
| 50–69 | 1.24 (0.96–1.60) | 0.097 | 1.36 (0.98–1.89) | 0.059 | 1.24 (0.95–1.61) | 0.112 | 1.43 (1.01–2.02) | 0.042 |
| ≥ 70 | 1.58 (1.21–2.05) | 0.001 | 2.05 (1.45–2.88) | <0.001 | 1.50 (1.14–1.97) | 0.004 | 1.93 (1.35–2.77) | <0.001 |
| T stage | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| T1 | Reference | Reference | Reference | <0.001 | Reference | |||
| T2 | 1.01 (0.87–1.16) | 0.946 | 1.22 (0.99–1.51) | 0.121 | 1.01 (0.87–1.18) | 0.903 | 1.24 (0.99–1.54) | 0.059 |
| T3 | 1.14 (0.97–1.33) | 0.115 | 1.36 (1.08–1.72) | 0.011 | 1.15 (0.97–1.36) | 0.105 | 1.32 (1.04–1.69) | 0.024 |
| T4 | 1.22 (1.06–1.41) | 0.005 | 1.80 (1.45–2.25) | <0.001 | 1.24 (1.07–1.44) | 0.004 | 1.75 (1.39–2.20) | <0.001 |
| N stage | 0.037 | – | 0.160 | |||||
| N0 | – | Reference | – | – | Reference | |||
| N1 | – | 0.87 (0.74–1.04) | 0.118 | – | – | 0.90 (0.75–1.07) | 0.241 | |
| N2 | – | 0.99 (0.81–1.19) | 0.872 | – | – | 0.98 (0.81–1.20) | 0.871 | |
| N3 | – | 1.08 (0.90–1.29) | 0.438 | – | – | 1.07 (0.88–1.29) | 0.506 | |
| Grade | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| High, I | Reference | Reference | Reference | Reference | ||||
| Intermediate, II | 1.28 (1.07–1.52) | 0.006 | 1.25 (0.94–1.66) | 0.121 | 1.29 (1.07–1.55) | 0.008 | 1.44 (1.05–1.98) | 0.026 |
| Low, III | 1.68 (1.40–2.01) | <0.001 | 1.81 (1.36–2.40) | <0.001 | 1.74 (1.44–2.10) | <0.001 | 2.10 (1.52–2.87) | <0.001 |
| Anaplastic, IV | 2.14 (1.36–3.37) | 0.001 | 1.73 (0.88–3.43) | 0.115 | 2.05 (1.26–3.35) | 0.004 | 2.24 (1.11–4.49) | 0.024 |
| Distant metastasis | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Bone only | Reference | Reference | Reference | Reference | ||||
| Liver only | 1.11 (0.92–1.35) | 0.287 | 1.66 (1.35–2.04) | <0.001 | 1.13 (0.92–1.38) | 0.250 | 1.57 (1.26–1.94) | <0.001 |
| Lung only | 1.02 (0.87–1.20) | 0.808 | 1.07 (0.88–1.29) | 0.514 | 1.05 (0.88–1.24) | 0.595 | 0.99 (0.81–1.21) | 0.942 |
| Brain only | 2.39 (1.63–3.49) | <0.001 | 2.44 (1.51–3.92) | <0.001 | 2.58 (1.76–3.77) | <0.001 | 2.23 (1.34–3.69) | 0.002 |
| Other site | 0.93 (0.79–1.10) | 0.410 | 0.90 (0.76–1.08) | 0.256 | 0.91 (0.77–1.09) | 0.317 | 0.83 (0.69–1.00) | 0.055 |
| Multiple sites | 1.57 (1.42–1.74) | <0.001 | 1.78 (1.53–2.06) | <0.001 | 1.62 (1.46–1.80) | <0.001 | 1.82 (1.56–2.12) | <0.001 |
| ER status | ||||||||
| Negative | Reference | Reference | Reference | Reference | ||||
| Positive | 0.57 (0.50–0.64) | <0.001 | 0.78 (0.66–0.91) | 0.002 | 0.58 (0.51–0.67) | <0.001 | 0.76 (0.64–0.89) | 0.001 |
| PR status | ||||||||
| Negative | Reference | Reference | Reference | Reference | ||||
| Positive | 0.71 (0.63–0.80) | <0.001 | 0.54 (0.46–0.63) | <0.001 | 0.68 (0.60–0.76) | <0.001 | 0.51 (0.43–0.59) | <0.001 |
| HER2 status | ||||||||
| Negative | Reference | Reference | Reference | Reference | ||||
| Positive | 0.61 (0.55–0.68) | <0.001 | 0.43 (0.37–0.49) | <0.001 | 0.60 (0.53–0.67) | <0.001 | 0.43 (0.37–0.50) | <0.001 |
| Radiation | ||||||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 1.10 (1.01–1.21) | 0.037 | 0.79 (0.71–0.89) | <0.001 | 1.12 (1.02–1.24) | 0.020 | 0.80 (0.71–0.90) | <0.001 |
| Chemotherapy | ||||||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 0.68 (0.62–0.75) | <0.001 | 0.74 (0.64–0.85) | <0.001 | 0.69 (0.62–0.76) | <0.001 | 0.74 (0.64–0.86) | <0.001 |
| Surgery type | ||||||||
| Lumpectomy/mastectomy | – | Reference | – | Reference | ||||
| Radical mastectomy | – | 1.10 (0.98–1.24) | 0.117 | – | 1.10 (0.97–1.25) | 0.136 | ||