Table 1.

Drug release kinetics profile of K. alvarezii extract-encapsulated PEGylated liposome

Model	Parameter	K. alvarezii extract from PEGylated liposome
		pH 3.2	pH 5.4	pH 7.4
Zero order F = K0 × t	K0	0.015	0.017	0.015
	r2 Adjusted	0.9001	0.9285	0.8961
	AIC	340.521	337.430	343.741
First order F = 100 × [1-Exp (-k1 × t)]	K1	0.01	0.01	0.01
	r2 Adjusted	0.9616	0.9692	0.9618
	AIC	300.411	302.144	301.786
Higuchi model F = KH × t1/2	Kh	0.904	1.026	0.926
	r2 Adjusted	0.8824	0.8878	0.8848
	AIC	347.390	356.379	348.114
Korsmeyer-Peppas model F = kKP × tn	kKP	0.1272	0.1078	0.140
	r2 Adjusted	0.9363	0.9535	0.9356
	n	0.742	0.778	0.733
	AIC	323.637	321.364	325.669
Hixon-Crowell model F = 100 × [1-(1-kHC × t)3]	kHC	0.001	0.001	0.001
	r2 Adjusted	0.9554	0.9741	0.9555
	AIC	306.618	294.757	308.127

Where, AIC akaike information criterion, F fraction of drug release in time t, K₀ apparent rate constant of zero-order release constant, K₁ first-order release constant, K_H higuchi constant, kKP Korsmeyer–Peppas rate constant, kHC Hixon–Crowell constant, n diffusional exponent. And r² squared correlation coefficient