Table 1.

Dysregulated genes in HCT116 p21–/– cells compared to HCT116 WT cells.

Gene	Unigene no.	RefSeq no.	Fold Change	p-value	Function	Active/repressive code
A: upregulated genes
DOT1La	Hs.713641	NM_032482	1.6625	0.02893	Histone methyltransferase	Repressive
DZIP3b	Hs.409210	NM_014648	1.7171	0.02113	Histone ubiquitination	Repressive
KMT2Ac	Hs.258855	NM_005933	1.5583	0.01501	Histone methyltransferase	Active
RPS6KA3d	Hs.445387	NM_004586	1.7695	0.01638	Histone phosphorylation	Active
SETD1Be	Hs.507122	NM_015048	1.7331	0.00850	Histone methyltransferase	Active
SETD2f	Hs.517941	NM_014159	1.4879	0.01639	Histone methyltransferase	Active
B: downregulated genes
AURKBg	Hs.442658	NM_004217	−2.25532	0.00003	Histone phosphorylation	Active
DNMT3Bh	Hs.713611	NM_006892	−2.17850	0.00497	DNA Methyltransferase	Repressive
ESCO2i	Hs.99480	NM_001017420	−2.77663	0.00497	Histone acetyltransferase	Active
HAT1j	Hs.632532	NM_003642	−2.05623	0.00621	Histone acetyltransferase	Active
HDAC1k	Hs.88556	NM_004964	−2.05148	0.03049	Histone deacetylase	Repressive
HDAC5l	Hs.3352	NM_001527	−3.76678	0.00621	Histone deacetylase	Repressive
HDAC11m	Hs.744132	NM_024827	−2.00926	0.00377	Histone deacetylase	Repressive
RPS6KA5n	Hs.510225	NM_004755	−2.06098	0.00621	Histone phosphorylation	Active
SETDB2o	Hs.631789	NM_031915	−2.40050	0.00621	Histone methyltransferase	Repressive

^aDOT1-like, histone H3 methyltransferase (S. cerevisiae).

^bDAZ interacting protein 3, zinc finger.

^cMyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila).

^dRibosomal protein S6 kinase, 90 kDa, polypeptide 3.

^eSET domain containing 1B.

^fSET domain containing 2.

^gAurora kinase B.

^hDNA (cytosine-5-)-methyltransferase 3 beta.

ⁱEstablishment of cohesion 1 homolog 1 (S. cerevisiae).

^jHistone acetyltransferase 1.

^kHistone deacetylase 1.

^lHistone deacetylase 5.

^mHistone deacetylase 11.

ⁿRibosomal protein S6 kinase, 90 kDa, polypeptide 5.

^oSET domain, bifurcated 2.