TABLE 3.
Potency obtained from the concentration-response curves.
| pEC50 |
|||||
| Y-C | O-S | O-CR | O-PE | O-CR-PE | |
| Phenylephrine | 6.26 ± 0.05 | 5.65 ± 0.02* | 6.04 ± 0.03& | 5.92 ± 0.04*,&, | 5.74 ± 0.02*,&,#,£ |
| Carbachol | 6.49 ± 0.03 | 6.04 ± 0.04* | 6.76 ± 0.04* | 6.52 ± 0.05# | 6.26 ± 0.03*,#,£ |
p < 0.05, * compared to Y-C; & compared to O-S; # compared to O-CR; £ compared to O-PE; n = 6. Potency (pEC50) represented as log of molar concentration to produce 50% of maximal contractile response elicited by agonist relative to KCl (118 mmol/L)-induced contraction.