Table 5.
The reclassification of each STs by the locus of major epitopes.
| DENV1 | DENV2 | DENV3 | DENV4 | JEV | WNV | YFV | ZIKV | |
|---|---|---|---|---|---|---|---|---|
| Major epitope locusa | E1 (28–46) | E1 (14–43) | E1 (28–46) | E1 (14–43) | E1 (14–29) | E1 (14–29) | E1 (19–29) | E1 (14–42) |
| E2 (96–109) | E2 (161–171) | E2 (161–171) | E2 (96–105) | E2 (96–105) | E2 (64–93) | E2 (70–84) | ||
| E3 (159–171) | E3 (197–218) | E3 (197–205) | E3 (143–168) | E3 (146–171) | E3 (147–183) | E3 (147–172) | ||
| E4 (204–219) | E4 (232–243) | E4 (209–218) | E4 (197–206) | E4 (193–205) | E4 (211–236) | E4 (197–205) | ||
| E5 (317–335) | E5 (268–281) | E5 (317–331) | ||||||
| E6 (317–346) | ||||||||
|
| ||||||||
| STb | 113 | 94 | 64 | 45 | 59 | 75 | 30 | 43 |
|
| ||||||||
| EpTc | 31 | 33 | 9 | 5 | 29 | 29 | 12 | 5 |
|
| ||||||||
| Frequency of major EpT (allelic profile) (%)d | EpT 1 (1-1-1-1) (73.9%) | EpT 1 (1-1-1-1-1) (31.5%) | EpT 1 (1-1-1-1) (84.3%) | EpT 1(1) (67.7%) | EpT 1 (1-1-1-1-1-1) (37.9%) | EpT 1 (1-1-1-1-1) (78.6%) | EpT 1 (1-1-1-1) (23.3%) | EpT 1 (1-1-1-1) (88.4%) |
| EpT 2 (1-6-5-1) (10.1%) | EpT 2 (1-1-3-1-1) (38.2%) | EpT 2 (1-1-1-1) (13.3%) | EpT 1(2) (24.4%) | EpT 1 (1-1-2-3-1-1) (30.7%) | EpT 2 (1-4-1-1) (20.6%) | |||
| EpT 3 (1-1-1-2) (5.9%) | ||||||||
aMajor epitope locus is the region in which the core peptides (Tables 1–4) are distributed. The number in parentheses is the amino acid sequence number. bSequence type (ST) was classified by the phylogenetic analysis. The numbers in this row represent the total sum of each ST. cAll the variations of epitopes were assigned allele numbers and combined into an allelic profile and assigned an epitope type (EpT). The numbers in this row represent the total sum of each EpT. dThe frequency registered on GenBank.