. 2020 Feb 13;2020:5068268. doi: 10.1155/2020/5068268

Table 3.

Identification results of varying ions and their change trend.

No.	Metabolite	VIP	RT (min)	Formula	Adduct	Calculated	Trend			Related pathway
No.	Metabolite	VIP	RT (min)	Formula	Adduct	Calculated	MG/HG	FTG/MG	WDG/MG	Related pathway
1☆	LysoPC (16:0)	11.93	10.11	C₂₄H₅₀O₇NP	[M+H]⁺	496.3398	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
2	LysoPC (18:1)	9.57	10.29	C₂₆H₅₂O₇NP	[M+H]⁺	522.3554	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
3☆	LysoPC (18:0)	9.41	11.25	C₂₆H₅₄O₇NP	[M+H]⁺	524.3711	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
4	LysoPC (18:2)	8.33	9.60	C₂₆H₅₀O₇NP	[M+H]⁺	520.3398	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
5	LysoPC (22:6)	6.61	9.61	C₃₀H₅₀O₇NP	[M+H]⁺	568.3398	↑^∗∗∗	↓^##	↓^&&&	Glycerophospholipid metabolism
6	LysoPE (16:0)	5.29	9.92	C₂₁H₄₄O₇NP	[M+H]⁺	454.2928	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
7	11-HETE	3.22	9.75	C₂₀H₃₂O₃	[M+H]⁺	321.2424	↑^∗∗∗	↓^###	↓^&&&	Arachidonic acid metabolism
8☆	Leucine	2.98	1.62	C₆H₁₃NO₂	[M+H]⁺	132.1019	↑^∗∗∗	↓^#	↓^&&&	Other
9☆	Glutamine	2.45	0.66	C₅H₁₀N₂O₃	[M+H]⁺	147.0764	↓^∗∗∗	↑^###	↑^&&&	Alanine, aspartate, and glutamate metabolism
10☆	5-Hydroxytryptamine	2.11	1.28	C₁₀H₁₂N₂O	[M+H]⁺	177.1022	↓^∗∗	↑	↑^&&&	Tryptophan metabolism
11☆	Tryptophan	2.02	3.59	C₁₁H₁₂N₂O₂	[M+H]⁺	205.0972	↓^∗∗∗	↑^###	↑^&&&	Tryptophan metabolism
12	Cystine	1.91	1.59	C₆H₁₂N₂O₄S₂	[M+H]⁺	241.0311	↑^∗∗	↓^#	↓	Other
13	Thromboxane B2	1.74	4.14	C₂₀H₃₄O₆	[M+H]⁺	371.2428	↓^∗∗∗	↑^###	↑^&&&	Arachidonic acid metabolism
14	LysoPE (22:6)	9.21	9.59	C₂₇H₄₄O₇NP	[M–H]^–	524.2783	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
15☆	Arachidonic acid	5.12	12.50	C₂₀H₃₂O₂	[M–H]^–	303.2331	↑^∗∗∗	↓^#	↓^&&&	Arachidonic acid metabolism
16☆	Pyruvic acid	3.98	0.87	C₃H₄O₃	[M–H]^–	87.0088	↑^∗∗∗	↓^###	↓^&&&	Pyruvate metabolism
17☆	α-Linolenic acid	3.16	12.04	C₁₈H₃₀O₂	[M–H]^–	277.2173	↓^∗∗∗	↓	↑^&	α-Linolenic acid metabolism
18☆	Palmitic acid	2.64	13.13	C₁₆H₃₂O₂	[M–H]^–	255.2329	↑^∗∗∗	↓^##	↓^&&	Other
19	9-HODE	2.37	10.21	C₁₈H₃₂O₃	[M–H]^–	295.2279	↑^∗∗∗	↓^###	↓^&&&	Linoleic acid metabolism
20☆	Histidine	1.85	0.62	C₆H₉N₃O₂	[M–H]^–	154.0622	↓	↓	↑^&&	Histidine metabolism

Note. ☆: confirmed with the reference substances. ↑: the compound is upregulated. ↓: the compound is downregulated. Represents the changes in MG compared with HG, ^∗p < 0.05, ^∗∗p < 0.01, p < 0.001; represents the changes in FTG compared with MG, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001; and represents the changes in WDG compared with MG, ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001.