TABLE 2.

Extracellular matrix protein-derived peptides as ligands to bind to cell surface receptors in drug delivery systems.

ECM molecules	Peptides	Cell receptor	Application	References
Collagen	GGYGGGP(GPP)5GFOGER(GPP)5GPC	α2β1	Local protein delivery	Shekaran et al., 2014
	(GPO)4GVKGDKGNPGWPGAP(GPO)4	Chondroitin sulfate modified CD44	Anti-cancer drug delivery	Ndinguri et al., 2012
	VCLCL-DDRT (Recombinant protein)	DDRs	Block the activity of cancer cell	An and Brodsky, 2016
ECM proteins	cRGD4C	αvβ3 and αvβ5	Anti-cancer drug delivery	Arap et al., 1998
	cRGDfC	αvβ3 and αvβ5	Anti-cancer drug delivery	Bibby et al., 2005
	cACRGDMFGCA	αvβ3 and αvβ5	VEGFR2-SiRNA delivery	Schiffelers et al., 2004
Laminin	RKRLQVQLSIRT	Syndecan	Anti-cancer drug delivery	Negishi and Nomizu, 2019
	DFKLFAVYIKYR-GGC (C16Y)	Integrin αvβ3	Anti-cancer drug delivery	Hamano et al., 2012