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. 2020 Feb 14;10:46. doi: 10.3389/fcimb.2020.00046

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Copyright © 2020 Benaim, Paniz-Mondolfi, Sordillo and Martinez-Sotillo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expanded model of Ca²⁺ regulating mechanisms within the parasites plasma membrane. Left: The sphingosine-stimulated Ca²⁺ channel, where the activation by Bay K 8466 and miltefosine and the inhibition by nifedipine and verapamil are depicted. Right: The CaM-stimulated PMCA, where the inhibition by pentamidine and crystal violet are shown (See text for explanations).