Table 4. Ex vivo permeability parameters of micellar formulation (F3), micelle loaded in situ gel (G4) and marketed preparation of Azelastine HCl across goat cornea.
| Formulation Code | % CDP (8th h) | % Enhancement Ratio (ER) |
r2 Value | Permeation Kinetics |
|---|---|---|---|---|
| F3 | 50.71 ± 0.87 | 5.87 | 0.9963 | Zero order |
| G4 | 43.35 ± 1.48 | 4.89 | 0.9944 | Zero order |
| MP | 14.64 ± 0.61 | 1.38 | 0.9632 | Zero order |
| Azelastine HCl suspension |
9.8 ± 0.45 | - | 0.9879 | Zero order |