Table 1. Clinical features and pathogens defining the presence of a bacterial OI.

Pathogen	Clinical Condition
Staphylococcus aureus [13], Streptococcus pneumoniae [13, 14], Listeria monocytogenes [13], Nocardia spp [14], Pseudomonas aeruginosa [15], Burkholderia cepacia [16], Escherichia coli [16], Klebsiella spp [16], Haemophilus influenzae [16], Serratia spp [16].	Multiple and recurrent infections (≥ 2 or more episodes within 12 months) in patients < 6 years: otitis media, pneumonia, sinusitis, skin-soft tissue. Recurrent pneumonia in patients aged ≥ 6 years. Invasive infections (bacteremia, osteomyelitis/arthritis, meningitis).
Salmonella spp [13]	Recurrent bacteremia.
Bartonella spp [14]	Disseminated disease, only.
Legionella pneumophila [17]	Pulmonary infection.
Mycobacterium tuberculosis [13, 14, 16, 19-21]	Reactivation of latent infection. Meningeal tuberculosis. Disseminated or extrapulmonary tuberculosis.
Bacillus Calmette–Guèrin (a live, attenuated strain of Mycobacterium bovis) [22]	Disseminated disease.
Non-tuberculous mycobacteria [13, 14, 16, 23, 24]	M. avium or M. kansasii, disseminated or extrapulmonary disease. Bacteremia due to other mycobacteria (e.g. M. iranicum).