Table 4. Clinical features and pathogens defining the presence of a protozoan OI.

Protozoa	Clinical Condition
Babesia spp [45, 46]	Severe disease with anemia, pulmonary and renal involvment; persisting and relapsing disease.
Toxoplasma gondii [15, 16, 19]	Toxoplasmosis of the central nervous system with onset at age ≥ 1 month. Visceral disseminated toxoplasmosis, (e.g. lungs).
Cryptosporidium [15, 16, 19]	Cryptosporidiosis, chronic diarrhea (>1 month duration).
Giardia [14, 15]	Giardiasis, chronic intestinal diarrhea >1 month duration).
Isospora [14, 15]	Chronic diarrhea (>1 month duration).
Microsporidium [14, 15]	Chronic diarrhea (>1 month duration) Anncaliia algerae myositis.
Leishmania [47, 48]	Recurrent, atypical visceral leishmania.
Trypanosoma cruzi [16, 49]	Reactivation of American trypanosomiasis: Meningoencephalitis, central nervous system mass, myocarditis.
Acanthamoeba spp. [50]	Meningoencephalitis, granulomatous amoebic encephalitis.
Balamuthia mandrillaris [51]	Meningoencephalitis, granulomatous amoebic encephalitis.
Naegleria fowleri [51]	Meningoencephalitis, granulomatous amoebic encephalitis.