Table 1.
Thromboelastometry conventional parameters. Median (5th–95th percentile) values are shown for each parameter
| Thromboelastometry parameters | Test category | Normal, n = 22 | Severe, HA, n = 30 | Severe, HA FVIII > 1, n = 11 | Moderate HA, n = 11 | Mild, HA, n = 16 |
|---|---|---|---|---|---|---|
| Clotting time (seconds) | CWB | 597 (354‐937) | 1783** (1132‐5524) | 1174 (852‐1620) | 1262 (772‐1580) | 1019 (641‐1328) |
| CWB+TF | 311 (186‐437) | 754 (372‐1779) | 795 (371‐929) | 486 (348‐757) | 483 (288‐1398) | |
| CWB+CT+TF | 412 (201‐612) | 1018 (464‐2832) | 983 (389‐2759) | 768.5 (374‐1652) | 727 (409‐1554) | |
| Clot formation time (seconds) | CWB | 247 (130‐459) | 537* (288‐1434) | 423 (326‐678) | 348 (216‐522) | 359 (177‐557) |
| CWB+TF | 117 (95‐290) | 291 (180‐587) | 304 (203‐395) | 211 (159‐326) | 211 (102‐323) | |
| CWB+CTI+TF | 178 (112‐280) | 544* (256‐1773) | 536 (235‐1372) | 413 (211‐524) | 366 (183‐738) | |
| α° | CWB | 49.5 (30.4‐61.9) | 28.5* (14.4‐44.6) | 32.5 (24‐42) | 36.5 (28‐44) | 37 (26‐57) |
| CWB+TF | 64 (51.0‐71.0) | 45 (26.5‐57) | 42 (34‐54) | 53 (40‐58) | 53 (42‐69) | |
| CWB+CTI+TF | 57.5 (47.0‐67.7) | 27.5 (10.9‐50.6) | 27 (20‐50) | 35 (28‐52) | 39 (26‐58) |
The median and the range (5th‐95th percentiles) thromboelastometry conventional parameters were calculated in the control group and 6 patient groups in 3 test categories.
Abbreviations: α°, alpha angle; CFT, clot formation time; CT, clotting time; CTI, corn trypsin inhibitor; CWB, citrated whole blood; HA, hemophilia A; TF, tissue factor.
*
P < 0.05 vs. moderate.
**
P <0.01 vs. moderate.