Table 2.
Thromboelastometry‐derived parameters. Median (5th–95th percentile) values are shown for each parameter
| Thromboelastometry parameters | Test category | Normal, n = 22 | Severe HA, n = 30 | Severe HA FVIII > 1, n = 11, median (5th‐95th percentile) | Moderate HA, n = 11, median (5th‐95th percentile) | Mild HA, n = 16 |
|---|---|---|---|---|---|---|
| Maximum velocity (mm/min) | CWB | 7.4 (5.1‐12.5) | 3 (1.2‐5.2) | 4 (3.0‐6.0) | 3.3 (2.0‐4.0) | 4 (3.0‐8.0) |
| CWB+TF | 10 (7.0‐15.2) | 5 (2.6‐8.3) | 6 (4.0‐7.3) | 5 (3.4‐8.3) | 7 (5.0‐12.0) | |
| CWB+CTI+TF | 9.0 (6.5‐13.7) | 3.0 (1.9‐6.3) | 4 (1.0‐5.8) | 3.5# (2.90‐4.9) | 5 (3.0‐8.0) | |
| Time to maximum velocity (minutes) | CWB | 9 (5.5‐13.5) | 38.7* (21.9‐92.0) | 23.1 (9.5‐31.6) | 25.9## (18.3‐33.0) | 19.7 (13.3‐26.8) |
| CWB+TF | 7.7 (3.5‐12.3) | 16.9 (9.8‐35.4) | 13.5 (8.4‐20) | 12.4## (10.8‐18.9) | 10.5 (6.6‐13.9) | |
| CWB+CTI+TF | 8.4 (4.7‐14.9) | 22.6 (9.3‐52.2) | 17.5 (8.9‐50) | 19.2 (12.5‐32.2) | 15.8 (10.1‐26.9) | |
| Area under the first derivative curve (mm) | CWB | 55 (43.6‐60.0) | 47.6 (27.8‐61.0) | 43.6 (30.8‐53.4) | 44.2 (39.7‐58.7) | 48.1 (35.4‐60.0) |
| CWB+TF | 58.8 (44.1‐82.0) | 51.6 (39.2‐69.5) | 48.8 (39.9‐56.9) | 49.1 (43.0‐63.4) | 53.6 (46.8‐62.6) | |
| CWB+CTI+TF | 55.5 (48.4‐62.3) | 48 (40.5‐68.3) | 49.4 (45.5‐57.4) | 51.6 (44.6‐65.0) | 52.5 (42.8‐62.0) |
The median and the range (5th‐95th percentiles) thromboelastometry‐derived parameters were calculated in control group and HA patients in 3 categories.
Abbreviations: CTI, corn trypsin inhibitor; CWB, citrated whole blood; FVIII, factor VIII; HA, hemophilia A; MaxVel, maximum velocity; TF, tissue factor.
*
P < 0.05 vs. moderate.
#
P < 0.05 vs. mild.
##
P < 0.01 vs. mild.