Table 2.
Patient characteristics and outcomes according to predicted risk tertiles
| Lowest tertile (N = 2103) | Middle tertile (N = 2135) | Highest tertile (N = 2221) | P value | |
|---|---|---|---|---|
| Treatment with betrixaban, n (%) | 1031 (49.0) | 1036 (48.5) | 1140 (51.2) | .15 |
| Treatment with enoxaparin, n (%) | 1073 (51.0) | 1099 (51.5) | 1081 (48.8) | .15 |
| Primary outcome event, n (%) | 58 (2.8) | 109 (5.1) | 240 (10.8) | <.001 |
| Age, y, mean (SD) | 73.83 (7.24) | 77.23 (7.40) | 77.78 (9.40) | <.001 |
| Male (%) | 988 (47.0) | 967 (45.3) | 969 (43.6) | .09 |
| Weight, kg, mean (SD) | 85.17 (20.56) | 78.53 (17.48) | 78.11 (18.68) | <.001 |
| BMI, kg/m2, median (IQR) | 29.60 (25.90‐35.50) | 28.10 (24.60‐32.10) | 27.50 (24.20‐32.00) | <.001 |
| Duration of hospitalization, days, median (IQR) | 9.00 (7.00‐13.00) | 10.00 (7.75‐14.00) | 11.00 (8.00‐15.00) | <.001 |
| Creatinine clearance, mL/min, mean (SD) | 75.84 (33.15) | 69.93 (31.32) | 68.08 (33.71) | <.001 |
| Race (%) | ||||
| White | 1996 (95.7) | 1992 (95.1) | 2075 (95.7) | .73 |
| Black | 37 (1.8) | 35 (1.7) | 44 (2.0) | |
| Asian | 4 (0.2) | 7 (0.3) | 2 (0.1) | |
| American Indian | 2 (0.1) | 3 (0.1) | 2 (0.1) | |
| Pacific Islander | 0 (0.0) | 1 (0.0) | 0 (0.0) | |
| Multiple | 14 (0.7) | 18 (0.9) | 12 (0.6) | |
| Other | 32 (1.5) | 39 (1.9) | 33 (1.5) | |
| Use of strong P‐gp inhibitor, n (%) | 383 (18.2) | 352 (16.5) | 426 (19.2) | .07 |
| D‐dimer, median (IQR) | 0.69 (0.39‐1.11) | 1.24 (0.76‐1.83) | 2.70 (1.52‐4.37) | <.001 |
| History of cancer, n (%) | 217 (10.3) | 275 (12.9) | 267 (12.0) | .031 |
| History of thrombosis, n (%) | 2 (0.1) | 13 (0.6) | 497 (22.4) | <.001 |
| Chronic heart failure, n (%) | 500 (23.8) | 467 (21.9) | 503 (22.6) | .33 |
| Acute infectious disease, n (%) | 313 (14.9) | 356 (16.7) | 340 (15.3) | .24 |
| Severe varicosities, n (%) | 475 (22.6) | 312 (14.6) | 414 (18.6) | <.001 |
| Hormone replacement, n (%) | 4 (0.2) | 14 (0.7) | 41 (1.8) | <.001 |
| Inherited or acquired thrombophilia, n (%) | 2 (0.1) | 2 (0.1) | 3 (0.1) | .89 |
BMI, body mass index; IQR, interquartile; P‐gp, P‐glycoprotein; SD, standard deviation.