Table II.

Clinicopathological and molecular factors in PTC.

A, Clinicopathological and molecular factors associated with lymph node metastasis in PTC
	Univariate analysis			Multivariate analysis
Variables	OR	95% CI	P-value	AOR	95% CI	P-value
Sex, female vs. male	1.469	0.548–3.937	0.445
Age, <45 vs. ≥45 years	2.214	0.933–5.257	0.072
Multifocal lesions, yes vs. no	1.163	0.382–3.544	0.791
Tumor size, >1 vs. ≤1 cm	6.394	2.457–16.393	<0.001a	6.394	2.208–18.182	0.001a
TNM stage, III–IV vs. I–II	3.048	1.258–7.384	0.014a	2.659	0.950–7.444	0.063
PPM1D protein expression
−	Reference	Reference
+	2.986	1.188–7.503	0.020a	2.512	0.852–7.406	0.095
++	4.071	0.713–23.623	0.114	5.446	0.809–36.661	0.081
B, Clinicopathological and molecular factors associated with tumor size >1 cm in PTC
	Univariate analysis			Multivariate analysis
Variables	OR	95% CI	P-value	AOR	95% CI	P-value
Sex, female vs. male	1.100	0.413–2.929	0.849
Age, <45 vs. ≥45 years	2.167	0.929–5.052	0.073
Multifocal lesions, yes vs. no	1.808	0.596–5.495	0.296
Extrathyroidal extension, yes vs. no	2.519	0.607–10.417	0.203
Bilateral lesions, yes vs. no	11.765	4.202–32.258	<0.001a	16.393	3.040–16.393	0.001a
PPM1D protein expression
−	Reference	Reference
+	0.442	0.179–1.092	0.077	0.455	0.137–1.512	0.199
++	5.158	0.568–46.834	0.145	17.218	1.393–212.831	0.027a

^aP<0.05. PTC, papillary thyroid carcinoma; OR, odds ratio; AOR, adjusted odds ratio.