Table 2.

Summary of FGF23-Mediated disorders of phosphate wasting and associated genetic & somatic mutations

Disorder	Genetic Mutation
X-linked Hypophosphatemic Rickets	PHEX
Autosomal Recessive Hypophosphatemic Rickets	DMP1, ENPP1, FAM20C
Autosomal Dominant Hypophosphatemic Rickets	FGF23
Fibrous Dysplasia (FD)/McCune-Albright Syndrome	GNAS
Tumor Induced Osteomalacia	FN1-FGFR1 fusion gene
Linear Nevus Sebaceous Syndrome	HRAS, KRAS, NRAS somatic mutations
Jansen’s Metaphyseal Chondrodysplasia	PTH/PTHrP receptor
Osteoglophonic Dysplasia	FGFR1