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. 2020 Feb 24;13:26. doi: 10.1186/s13041-020-00568-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Increased baseline Fabp7 mRNA expression, and disruption of its circadian rhythm, in Bmal1 KO. (a) Average expression of hypothalamic Fabp7 mRNA is ~7fold greater in BMAL KO compared to WT mice, while Fabp3 mRNA and Fabp5 mRNA are stable (n = 18 per group). ***p < 0.001 Fabp7 mRNA KO/WT vs. Fabp3 mRNA or Fabp5 mRNA KO/WT (t-test). (b) Normalized mRNA expression values (to mean of circadian values within each group) of various Fabps depicts the circadian oscillation of Fabp7 mRNA in C57BL/6 WT which is absent in BMAL KO mice (n = 3 per group per timepoint). Fabp7 mRNA shows a significant circadian dependent change in expression based on genotype. Two-way ANOVA (p < 0.001). ***p < 0.001, **p < 0.01, *p < 0.05 vs ZT0 (post-hoc Bonferroni), while there is no significant difference for circadian variation of Fabp7 mRNA in BMAL KO mice