Table III.

Univariate and multivariate analysis of various prognostic variables influencing RFS in HCC patients.

		Univariate analysis		Multivariate analysis
Variables	n	HR (95% CI)	P-value	HR (95% CI)	P-value
Sex		0.672 (0.486–1.485)	0.509
Male	34
Female	26
Age (years)		0.537 (0.389–1.059)	0.543
<50	28
≥50	32
Tumor size (cm)		0.473 (0.571–1.839)	0.005	0.634 (1.007–2.310)	0.013
≤5	27
>5	33
AFP (ng/ml)		1.539 (1.409–2.847)	0.733
≤20	27
>20	33
HBsAg		1.003 (0.984–1.530)	0.527
Positive	37
Negative	23
TNM stage		1.219 (0.347–1.595)	0.010	1.180 (1.038–2.641)	0.015
I/II	27
III/IV	33
Multiplicity		0.495 (0.671–1.734)	0.034	0.834 (0.734–1.995)	0.027
Single	24
Multiple (≥2)	36
Vascular invasion		1.045 (1.048–3.618)	0.649
Presence	27
Absence	33
Liver cirrhosis		1.217 (1.257–2.804)	0.806
Presence	32
Absence	28
Intrahepatic metastasis		0.673 (0.758–2.645)	0.587
Presence	25
Absence	35
miR-29c-3p expression		1.148 (0.687–1.694)	0.019	1.327 (1.224–2.647)	0.014
Low	39
High	21

RFS, recurrence-free survival; HCC, hepatocellular carcinoma.