Table 3.
Multivariate analysis of various factors correlated with progression-free survival
| No. of patients | PFS | ||
|---|---|---|---|
| Multivariate analysis | |||
| HR (95% CI) | P | ||
| Age, years (continuous) | 168 | 1.025 (0.956–1.099) | 0.4894 |
| LC | |||
| 2006~2012 | 77 | 1 (Reference) | |
| 2013~2018 | 91 | 0.065 (0.007–0.603) | 0.0162* |
| BMI | |||
| < 25 | 130 | 1 (Reference) | |
| ≥ 25 | 38 | 0.243 (0.025–2.404) | 0.2264 |
| Stage | |||
| IB1, IB2 | 141 | 1 (Reference) | |
| IA1, IA2 | 27 | 0.638 (0.092–4.446) | 0.6502 |
| Histology | |||
| SCC | 118 | 1 (Reference) | |
| AC & AS | 50 | 1.367 (0.375–4.986) | 0.6357 |
| Invasiveness | |||
| < 0.3 cm | 97 | 1 (Reference) | |
| ≥ 0.3 cm | 71 | 1.139 (0.297–4.363) | 0.8493 |
| LVSI | |||
| No | 128 | 1 (Reference) | |
| Yes | 40 | 4.590 (0.973–21.659) | 0.0543 |
| No. of harvested LNs | |||
| < 20 | 129 | 1 (Reference) | |
| ≥ 20 | 39 | 0.325 (0.068–1.557) | 0.1597 |
| Metastatic LNs | |||
| No | 155 | 1 (Reference) | |
| Yes | 13 | 2.609 (0.424–16.041) | 0.3006 |
| Tumor size | |||
| < 2 cm | 125 | 1 (Reference) | |
| ≥ 2 cm | 43 | 5.651 (1.255–25.448) | 0.0241* |
| Postoperative treatment | |||
| Yes | 34 | 1 (Reference) | 0.0755 |
| No | 134 | 0.185 (0.029–1.189) | |
PFS Progression-free survival, HR Hazard ratio, CI Confidential interval, LC Learning curve, BMI Body mass index, SCC Squamous cell carcinoma, AC Adenocarcinoma, AS Adenosquamous, LVSI Lymphovascular space invasion, LN Lymph node; *, P < 0.05