FIG. 6.

Distribution of peak inhalation flow rates and pressures through various DPIs. (A) As expected, given the data in Figure 3, adults with asthma generate the most favorable inhalation maneuvers and children with asthma the weakest, with chronic obstructive pulmonary disease subjects performing slightly better than the children. Also as expected given the data in Figure 1, subjects generated higher flows through lower resistance devices (AERO, DSK) compared with higher resistance devices (TBH, EASY). (B) The equivalent distribution of pressure drops. In contrast to the peak inhalation flows (A), the pressure changes tended to be slightly greater for DPIs with a higher resistance (TBH, EASY) than those with a lower resistance (AERO, DSK). Boxes represent interquartile range with the median, and whiskers show the full range of the data, with outliers shown as circles. Reproduced from Azouz et al.⁽¹⁸⁾ with permission. AERO, Aerolizer; DSK, Diskus; EASY, Easyhaler; TBH, Turbuhaler. Color images are available online.