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. 2019 May 10;6(1):17–58. doi: 10.5194/pb-6-17-2019

Figure 9.

Figure 9

Clinical and pathological aspects of an atypical EAE model induced with MOG34-56/IFA. Immunization with MOG34-56/IFA at a 28 d interval (arrows) induces 100 % clinical EAE with a variable time of onset. Notice that the only information relayed to the marmoset's immune system is the sequence of 23 letters (CTL core epitope in red). Immunostaining for PLP shows lesions in the white and grey matter (A). Rectangle 1 indicates a demyelinated region in the cingulate cortex, which is characterized by complete demyelination (B), presence at the lesion edge of macrophages containing a PLP+ inclusion particle (C), activated MRP14+ microglia (E) and depletion of oligodendrocytes (F). Immune cells (CD3) were only detected in meninges. Rectangle 2 (A) indicates a leukocortical and an intracortical lesion (G), which are also depleted from oligodendrocytes (H) and contain abundant MRP14+ microglia. Mf is macrophage, TPPP is tubulin polymerization-promoting protein, ODC is oligodendrocyte.