Figure 15.

Effect of the dietary modification (2014) on incidence of EAE and CalHV3 infection in the BPRC marmoset colony. Since the discovery in 2012 that full-blown clinical EAE could be induced with the rhMOG/IFA model, 19 marmosets have been tested. (a) Time to clinical score 2 (disease-free survival) or the clinical endpoint (overall survival) of monkeys tested before ($n=\mathrm{13}$ marmosets, water-based supplement is WBS) and after ($n=\mathrm{6}$ marmosets) the introduction of the yogurt-based supplement (YBS). The graphs show a significant effect of the dietary modification on the incidence and course of EAE (log-rank test). (b) Periodic blood samples were collected from the colony at the dates on the $x$ axis and tested for the presence of CalHV3 DNA using qPCR. The percentages of monkeys tested positive and negative for the viral DNA are given on the $y$ axis. The figure shows that after the dietary change the percentage of monkeys in which CalHV3 could be detected was reduced from $\pm \mathrm{70}$ % to $\pm \mathrm{30}$ %.