TABLE 3.

Performances of the MeningoSpeed RDT by comparison to the IPP RT-PCR assay used as reference standard for the serogroup determination of the 319 specimens found positive for Neisseria meningitis by PCR^a

Parameterb	Values by serogroup, determined by PCR
	A	C	W	X	Y
No. of CSF+ samples by PCR	43	47	159	58	12
Sensitivity (95% CI)	0.930 (0.799–0.981)	0.744 (0.594–0.856)	0.981 (0.942–0.945)	1 (0.923–1)	0.883 (0.509–0.970)
Specificity (95% CI)	0.990 (0.976–0.996)	1 (0.990–1)	0.980 (0.960–0.990)	0.986 (0.976–0.994)	1 (0.991–1)
PPV (95% CI)	0.889 (0.751–0.958)	1 (0.877–1)	0.951 (0.903–0.978)	0.892 (0.784–0.952)	1 (0.655–1)
NPV (95% CI)	0.994 (0.982–0.998)	0.977 (0.959–0.988)	0.992 (0.976–0.998)	1 (0.990–1)	0.996 (0.985–0.999)
Cohen’s kappa coefficient (95% CI)	0.901 (0.834–0.969)	0.842 (0.755–0.930)	0.952 (0.924–0.980)	0.936 (0.889–0.983)	0.907 (0.780–1)

^aAfter exclusion of the 10 samples serogrouped as NmB, as this antigen was absent from the RDT.

^bPPV,: positive predictive value; NPV, negative predictive value.