TABLE 4.
Respective sensitivity and specificity of RDT by comparison to PCR as referenced in different studies of the literaturea
| Reference and yr | Type of RDT | No. of CSF samples | Origin of CSF samples | Serogroup | % Sensitivity (95%CI) | % Specificity (95% CI) |
|---|---|---|---|---|---|---|
| (11) 2006 | LA | 484 | Niger 2003 | A | 88 (85–91) | 93 (90–95) |
| (12) 2009 | LA | 126 | Niger 2006 | A | 69 (57–79) | 81 (68–91) |
| Dipstick | 89 (80–95) | 62 (48–75) | ||||
| (15) 2010 | Dipstick | 265 | Burkina Faso 2007 | A | 70.0 (55.4–82.1) | 97.0 (93.4–98.7) |
| (16) 2013 | Dipstick | 401 | France, Burkina Faso, Niger | A | 88 (81–92) | 99 (98–100) |
| (17) 2014 | Dipstick | 1,113b | Niger 2008–2012 | 87.6 (85.7–89.3) | 85.7 (83.1–87.2) | |
| 1,162c | Niger 2008–2012 | A/W | 92.5 (89.8–92.9) | 84.6 (82.0–86.9) | ||
| (18) 2015 | Dipstick | 369 | Cameroon, Côte d’Ivoire, Niger, France | X | 94 (86–98) | 100 (99–100) |
| (13) 2016 | LA | 63 | Nigeria 2013–2015 | C | 80.0 (65.4–90.4) | 94.4 (72.7–99.9) |
| This study 2019 | Dipstick | 560 | Niger, Côte d’Ivoire, République Centre-Africaine, Togo, France | A | 93.0 (79.9–98.1) | 99.0 (97.6–99.6) |
| C | 74.4 (59.4–85.6) | 100 (99.0–100) | ||||
| W | 98.1 (94.2–99.5) | 98.0 (96.0–99.0) | ||||
| X | 100 (92.3–100) | 98.6 (97.6–99.4) | ||||
| Y | 83.3 (50.9–97.0) | 100 (99.1–100) |
a
RDT, rapid diagnostic test; CSF, cerebrospinal fluid; LA, latex agglutination.
b
Tested in point of care.
c
Tested in reference laboratory.