TABLE 3.
Agreement between phenotypic MIC values and resistance genotype
| Antibiotic | MIC (μg/ml) breakpoint | Genotype | No. of isolates with the following phenotype: |
Kappa coefficient (95% CI) | P value by Fisher’s exact test | Adjusted P value | |
|---|---|---|---|---|---|---|---|
| Sensitive | Resistant | ||||||
| Amoxicillina | >0.125 | Sensitive | 39 | 0 | 1 (1.0–1.0) | <0.0001 | 0.0007 |
| Resistant | 0 | 3 | |||||
| Clarithromycin | >0.5 | Sensitive | 26 | 0 | 0.84 (0.67–1.0) | <0.0001 | 0.0007 |
| Resistant | 3 | 13 | |||||
| Levofloxacin | >1 | Sensitive | 17 | 1 | 0.9 (0.77–1.0) | <0.0001 | 0.0007 |
| Resistant | 1 | 23 | |||||
| Tetracycline | >1 | Sensitive | 38 | 0 | 1.0 | 1.0 | |
| Resistant | 4 | 0 | |||||
| Metronidazoleb | >8 | Sensitive | 20 | 2 | 0.76 (0.56–0.96) | <0.0001 | 0.0007 |
| Resistant | 3 | 17 | |||||
| Rifampinc | >1 | Sensitive | 29 | 8 | 0.46 (0.18–0.75) | 0.0015 | 0.0105 |
| Resistant | 0 | 5 | |||||
| >4 | Sensitive | 37 | 0 | 0.73 (0.37–1.0) | <0.001 | 0.0063 | |
| Resistant | 2 | 3 | |||||
a
Genetic resistance was defined as mutations near putative amoxicillin binding motifs.
b
Genetic resistance was defined as a truncation in rdxA or an R16H mutation.
c
Genetic resistance was defined as any mutation in rpoB.