TABLE 2.

Yeast-phase MIC distribution of Blastomyces isolates (9 B. percursus isolates, 8 B. emzantsi isolates, and 1 B. dermatitidis isolate [ATCC 10225])^a

Case (GenBank accession no.; isolate)	Reference(s)	Etest MIC (mg/liter)				BMD MIC (mg/liter)
		AMB	VRC	POS	ITC	FLC	VRC	POS	ITC	5FC	CAS	MFG	ANG
Group 1 (Blastomyces percursus)
1 (QKWI00000000; NCPF 4091)	5	0.004	0.002	0.002	0.002	4	0.008	0.008	0.008	64	0.06	0.008	0.12
2 (LGTZ00000000; BP222)	17, 18	0.064	0.002	0.002	0.002	8	0.03	0.25	0.25	256	0.5	0.12	0.12
3 (QGQT00000000; SA-NICD-06)	17	0.012	0.002	0.002	0.002	1	0.008	0.03	0.06	128	0.5	0.06	0.5
4 (QGQR00000000; SA-NICD-08)	This study	0.047	0.002	0.002	0.002	4	0.015	0.008	0.015	256	1	0.03	2
5 (QGQS00000000; SA-NICD-05)	21	0.094	0.012	0.002	0.003	8	0.015	0.008	0.008	32	4	0.12	1
6 (QGQQ00000000; SA-NICD-04)	3, 4	0.003	0.002	0.002	0.002	0.25	0.008	0.008	0.008	32	0.5	0.03	4
7
SA-NICD-18	19	0.003	0.002	0.002	0.002	0.5	0.008	0.008	0.008	32	1	0.03	0.5
QGQP00000000; SA-NICD-03	This study	0.004	0.002	0.002	0.002	2	0.015	0.008	0.008	32	0.5	0.12	0.5
QGQN01000000; SA-NICD-07	This study	0.004	0.002	0.002	0.002	2	0.015	0.015	0.03	16	0.5	0.015	0.25
MIC range		0.003–0.094	0.002–0.012	0.002–0.002	0.002–0.003	0.25–8	0.008–0.03	0.008–0.25	0.008–0.25	32–256	0.06–4	0.008–0.12	0.12–4
GM		0.02	0.002	0.002	0.002	2	0.01	0.02	0.02	59.26	0.59	0.03	0.54
ATCC		0.002	0.002	0.002	0.002	0.5	0.015	0.12	0.06	256	2	8	2
Group 2 (Blastomyces emzantsi)
8 (QGQJ00000000; SA-NICD-13)	20	0.25	0.002	0.002	0.006	2	0.015	0.008	0.03	128	2	0.06	1
9 (QGQI00000000; SA-NICD-15)	20	0.25	0.002	0.002	0.003	2	0.008	0.008	0.015	32	1	0.06	1
10
QGQK00000000; SA-NICD-14	3, 4	0.023	0.003	0.002	0.002	1	0.008	0.008	0.008	16	2	0.06	1
QGQL00000000; SA-NICD-16	This study	0.002	0.002	0.002	0.002	1	0.008	0.008	0.008	64	1	0.03	0.5
QGQE00000000; SA-NICD-12	This study	0.032	0.002	0.002	0.002	2	0.015	0.008	0.008	128	4	0.06	2
QGQF00000000; SA-NICD-09	This study	0.047	0.002	0.004	0.008	4	0.03	0.008	0.12	64	0.5	0.008	1
QGQG00000000; SA-NICD-10	This study	0.047	0.002	0.003	0.016	2	0.008	0.008	0.008	64	4	0.03	2
QGQH00000000; SA-NICD-11	This study	0.64	0.002	0.002	0.002	0.25	0.008	0.008	0.008	16	1	0.03	0.5
MIC range		0.002–0.64	0.002–0.003	0.002–0.004	0.002–0.016	0.25–4	0.008–0.03	0.008–0.008	0.008–0.12	16–128	0.5–4	0.008–0.3	0.5–2
GM		0.06	0.002	0.002	0.004	1.41	0.01	0.01	0.01	49.35	1.54	0.03	1

^aBMD, broth microdilution; GM, geometric mean; ATCC, B. dermatitidis ATCC 10225; AMB, amphotericin B; VRC, voriconazole; POS, posaconazole; ITC, itraconazole; FLC, fluconazole; 5FC, 5-flucytosine; CAS, caspofungin; MFG, micafungin; ANG, anidulafungin.