TABLE 3.

Mold-phase MIC distribution of Blastomyces isolates (9 B. percursus isolates, 8 B. emzantsi isolates, and 1 B. dermatitidis isolate [ATCC 10225])^a

Case (GenBank accession no.; isolate	Reference(s)	Etest MIC (mg/liter)				BMD MIC and MEC (mg/liter)
		AMB	VRC	POS	ITC	FLC	VRC	POS	ITC	5FC	CAS	MFG	ANG
Group 1 (Blastomyces percursus)
1 (QKWI00000000; NCPF 4091)	5	0.008	0.002	0.002	0.002	0.5	0.008	0.06	0.12	256	0.12	0.06	0.25
2 (LGTZ00000000; BP222)	17, 18	0.004	0.002	0.002	0.012	4	0.008	0.06	0.03	64	0.06	0.008	0.008
3 (QGQT00000000; SA-NICD-06)	17	0.008	0.002	0.002	0.012	2	0.008	0.015	0.03	256	0.5	0.25	0.5
4 (QGQR00000000; SA-NICD-08)	This study	0.012	0.002	0.012	0.006	2	0.008	0.06	0.06	32	0.5	0.03	4
5 (QGQS00000000; SA-NICD-05)	21	0.002	0.002	0.002	0.003	2	0.008	0.008	0.015	256	1	0.03	0.25
6 (QGQQ00000000; SA-NICD-04)	3, 4	0.002	0.002	0.002	0.003	2	0.008	0.015	0.03	64	0.5	0.03	0.25
7
SA-NICD-18	19	0.064	0.002	0.002	0.004	2	0.008	0.008	0.06	128	2	0.06	1
QGQP00000000; SA-NICD-03	This study	0.002	0.002	0.002	0.003	0.12	0.008	0.008	0.008	8	0.25	0.008	0.12
QGQN01000000; SA-NICD-07	This study	0.002	0.002	0.002	0.002	4	0.008	0.06	0.12	256	0.5	0.03	0.25
MIC range		0.002–0.064	0.002–0.002	0.002–0.012	0.002–0.012	0.12–4	0.008–0.008	0.008–0.06	0.015–0.12	8–256	0.06–2	0.008–0.25	0.008–4
GM		0.01	0.002	0.002	0.004	1.46	0.01	0.02	0.04	94.06	0.39	0.03	0.27
ATCC		0.002	0.002	0.002	0.012	0.5	0.008	0.06	0.03	256	1	8	2
Group 2 (Blastomyces emzantsi)
8 (QGQJ00000000; SA-NICD-13)	20	0.25	0.004	0.002	0.012	4	0.008	0.06	0.12	256	4	0.25	1
9 (QGQI00000000; SA-NICD-15)	20	0.094	0.006	0.002	0.016	4	0.008	0.015	0.06	128	1	0.25	0.5
10
QGQK00000000; SA-NICD-14	3, 4	0.032	0.002	0.003	0.03	1	0.008	0.008	0.008	128	0.5	0.06	0.5
QGQL00000000; SA-NICD-16	This study	0.47	0.002	0.002	0.003	1	0.008	0.008	0.008	128	4	0.25	1
QGQE00000000); SA-NICD-12	This study	1	0.002	0.002	0.012	1	0.015	0.008	0.008	128	1	0.12	2
QGQF00000000; SA-NICD-09	This study	0.19	0.002	0.002	0.006	8	0.015	0.008	0.06	128	4	0.12	2
QGQG00000000; SA-NICD-10	This study	0.64	0.002	0.002	0.012	2	0.008	0.03	0.06	128	2	0.12	1
QGQH00000000; SA-NICD-11	This study	0.5	0.002	0.002	0.006	2	0.008	0.015	0.06	128	2	0.06	0.5
MIC range		0.032–1	0.002–0.006	0.002–0.003	0.003–0.03	1–8	0.008–0.015	0.008–0.06	0.008–0.12	128–256	0.5–4	0.06–0.25	0.5–2
GM		0.26	0.002	0.002	0.01	2.18	0.01	0.01	0.03	139.59	1.83	0.13	0.92

^aBMD, broth microdilution; GM, geometric mean; ATCC, B. dermatitidis ATCC 10225; AMB, amphotericin B; VRC, voriconazole; POS, posaconazole; ITC, itraconazole; FLC, fluconazole; 5FC, 5-flucytosine; CAS, caspofungin; MFG, micafungin; ANG, anidulafungin.