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. 2020 Feb 21;13:1625–1635. doi: 10.2147/OTT.S241367

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© 2020 Chen et al.

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Activation of the MAPK/ERK signaling pathway was involved in FOXC2-regulated oxaliplatin resistance. (A) The ERK1/2 and phospho-ERK1/2 levels after FOXC2 silencing in OXA-resistant HCT116/OXA cells were determined by Western blotting. (B) Western blotting detection of E-cadherin, Vimentin, ERK1/2 and phospho-ERK1/2 proteins in HCT116/FOXC2 cells after MAPK/ERK kinase inhibitor SCH772984 treatment. GAPDH served as an internal control. (C) MAPK/ERK kinase inhibitor SCH772984 could reduce the IC₅₀ of OXA in HCT116/FOXC2 cells (p < 0.05). IC50 values of HCT116/FOXC2 group: 13.65 ± 0.92μM, HCT116/FOXC2+ SCH772984 group: 25.85 ± 3.09μM. All values stand for the average of three independent experiments (means ± SDs). *p < 0.05, **p < 0.01, ***p < 0.001.