Table 2.
Lipid Composition of Control and ALD White Matter Samples
| Water content, total lipids and lipid composition of control and adrenoleukodystrophy white matter samples | Control | ALD intact | ALD active | ALD gliotic |
|---|---|---|---|---|
| Water content (%) | 73 | 65 | 75 | 89 |
| Total lipids (% dry weight) | 54.9 | 51.5 | 44.4 | 17 |
| Free cholesterol (% of total lipids) | 29.7 | 25.2 | 3.9 | 25.3a |
| Cholesterol ester (% of total lipids) | Trace | 0.5 | 31 | 1.3a |
| Phospholipids (% of total lipids) | 33.7 | 42.2 | 41.8 | 41.3a |
| Galactolipids (% of total lipids) | 36.6 | 31.3 | 22.9 | 4a |
| Phosphatidylcholine (VLCFA as % total fatty acid) | 1.57 | 10.36 | 16.66 | |
| Phosphatidylethanolamine (VLCFA as % total fatty acid) | 0.12 | 1.82 | 0.72 | |
| Phosphatidylserine (VLCFA as % total fatty acid) | 2.49 | 0.73 | 1.08 | |
| Phosphatidylinositol (VLCFA as % total fatty acid) | 1.05 | 2.68 | 3.21 | |
| Gangliosides (C24:0 fatty acid as % total fatty acids) | 2.95 | 4.3 | 10.22 | 14.64 |
a
Triglycerides and free fatty acids: 28.1% of total lipids.