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. 2020 Jan 8;161(2):bqz044. doi: 10.1210/endocr/bqz044

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Biological pathways associated with hypothalamic genes dysregulated by soybean oil (SO)-rich high-fat diets. A, Venn diagram showing number of genes dysregulated (≥ 1.5-fold, P and Padj ≤ .05) either exclusively or commonly by SO + CO and PL + CO vs CO and gene ontology for biological pathways altered in the comparisons shown. B, Absolute expression levels from RNA sequencing of dysregulated genes (≥ 1.5 fold, P and Padj ≤ .05) in the most prominent pathways. Significantly different from ^#CO, *Viv chow. CO diets enriched in conventional soybean oil (SO + CO), genetically modified Plenish (PL + CO), and stigmasterol (ST + CO).