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. 2020 Jan 8;161(2):bqz044. doi: 10.1210/endocr/bqz044

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Oxt is the only gene dysregulated in both soybean oil diets (vs CO and Viv chow) that is associated with neurological, metabolic, and inflammation disease categories. A, Venn diagram showing overlap in hypothalamic genes from RNA sequencing (RNA-seq) related to neurological diseases vs metabolic diseases and inflammation dysregulated in SO + CO and PL + CO vs CO (Tables 5 and 6). B, Absolute expression levels from RNA-seq data of 6 of the 9 common genes. Significantly different from ^#CO, *Viv chow. C, Venn diagram showing overlap in genes related to metabolic diseases (obesity, diabetes, and lipid metabolism), inflammation, and neurological diseases that are dysregulated in the hypothalamus of both soybean oil diets vs CO diet. Oxytocin (Oxt, red font) is the only gene common to all 3 disease categories and is significantly different both from CO and Viv chow. CO diets enriched in conventional soybean oil (SO + CO), genetically modified Plenish (PL + CO), and stigmasterol (ST + CO).