Figure 6.

Obesogenic and diabetogenic effects of soybean oil (SO) diets with high or low linoleic acid (LA) is not mimicked by stigmasterol. A, Average weekly body weights of male C57BL/6N mice started on the indicated diets at weaning (N = 6-12/diet) as in Fig. 1A. All diets were isocaloric with 40 kcal% total fat except Viv chow, which had 13.4 kcal% fat. B, Glycemia (mg/dL) measured during a glucose tolerance test (GTT) depicted as area under the curve after 16 weeks on diet (N = 6–12/diet). C, Average weekly food consumption of mice on various diets measured on a per-cage basis and normalized to the number of mice per cage. Food was changed and measured twice weekly; values were combined to generate the weekly average. Consumption of Viv chow was highest because this diet has the fewest calories per gram (N = 6-12 mice [3-4 cages]/diet). ^@Statistical difference between PL + CO and ST + CO at 12 weeks on diet. Statistically different from ^#CO, ^%ST + CO, ^&all others using one-way analysis of variance followed by Tukey post hoc analysis for B or two-way ANOVA followed by Tukey post-hoc analysis for A and C.