Table 5.
Dysregulated hypothalamic genes related to metabolic disease and inflammation in male mice (P ≤ .05, q ≤ 0.05, FC ≥ 1.5)
| Metabolic Disease | ||||
|---|---|---|---|---|
| Diet | Diabetes | Lipid Metabolism | Obesity | Inflammation |
| SO + CO vs CO | Oxt, Mmp11, Hcrt, Avp, Hsd11b1, Gck, Hdc, Cartpt | Hsd11b1, Ghsr, Gck, Abhd8, Hsd17b7 | Mc3r, Hsd11b1, Hcrt, Ghsr, Gal, Gck, Cartpt, Gpx3, Dio2 | C1qtnf4, Oxt, Hsd11b1, Ghsr, Cartpt, Nr4a2, Dio2, Sema7a |
| PL + CO vs CO | Hcrt, Mmp11, Oxt, Avp, Cartpt, Mt1 | Abhd8 | Hcrt, Cartpt, Mt1 | C1qtnf4, Oxt, Crlf2, Cartpt, Mt1 |
| CO vs Viv | 0 | 0 | 0 | Atp2a1, Rgs16 |
Genes are presented in order of decreasing fold-change.
Abbreviations: CO, coconut oil; PL, Plenish; SO, soybean oil; Viv, vivarium chow.