Table 6.
Dysregulated hypothalamic genes related to neurological disease in male mice (P ≤ .05, q ≤ 0.05, FC ≥ 1.5)
| Diet | Alzheimer’s | Anxiety | Autism | Depression | Pain | Parkinson’s | Schizophrenia |
|---|---|---|---|---|---|---|---|
| SO + CO vs CO | Pcsk1n, Gal, Irs4,Ngb, Nrn1 | Oxt, Hcrt, Avp, Gal, Hdc,Dio2, Baiap3 | Oxt | Oxt, Hcrt, Avp, Gal, Dio2 | Oxt, Hcrt, Ghsr Gal, Prkcg | Ghsr, Nr4a2 | Nr4a2 |
| PL + CO vs CO | Pcsk1n | Hcrt, Oxt, Avp | Oxt, Nrxn2 | Hcrt, Oxt, Avp, Mt1 | Hcrt, Oxt | 0 | Nrxn2 |
| CO vs Viv | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genes are presented in order of decreasing fold-change.
Abbreviations: CO, coconut oil; PL, Plenish; SO, soybean oil; Viv, vivarium chow.