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. 2020 Jan 13;219(2):e201912006. doi: 10.1083/jcb.201912006

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© 2020 Leterrier

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Figure 1. — AIS-located proteasomes degrade chloride transporters and drive GABA response reversal. Proteasomes associated with the adaptor Ecm29 (green) are transported to the AIS by kinesins along microtubules (gray). Here, they interact with ankyrin G (ankG; brown) and degrade NKCC1 chloride transporters (blue). This shifts the NKCC1 import/KCC2 export (orange) equilibrium, reducing the intracellular chloride concentration and shifting the GABA response from excitatory to inhibitory.