Table 1. The effects of AU on osteoblast differentiation related factors in peripheral blood of Dex-injected mice with osteoporosis.
| Groups | CTRL | AU (15mg/kg) | -- | E2 (15 μg/kg) | Dex(30mg/kg) | ||
| AU (mg/kg) | |||||||
| 5 | 15 | 45 | |||||
| Ca (mmol/L) | 1.5±0.1 | 1.4±0.1 | 1.3±0.1# | 1.6±0.1** | 1.5±0.1* | 1.5±0.1* | 1.5±0.1* |
| Pi (mmol/L) | 2.3±0.2 | 2.4±0.2 | 2.1±0.1# | 2.4±0.2** | 2.4±0.2* | 2.4±0.3* | 2.2±0.2 |
| E2 (pmol/L) | 45.1±2.5 | 44.4±1.3 | 40.6±1.2# | 44.5±2.5* | 44.2±3.3 | 44.0±6.0 | 51.3±0.1** |
| ALP (IU/L) | 8.1±1.8 | 7.7±1.5 | 5.1±1.0## | 7.5±1.3** | 6.6±1.0* | 7.7±0.8** | 6.4±0.3** |
| Collagen I (ng/mL) | 5.2±0.6 | 5.1±0.6 | 4.1±0.4## | 4.8±0.7* | 5.0±0.7* | 5.7±0.8*** | 5.6±0.7*** |
| OCN (ng/mL) | 2.4±0.2 | 2.6±0.3 | 2.0±0.2## | 2.3±0.2* | 2.3±0.1** | 2.6±0.3** | 2.3±0.2* |
| OPN (ng/mL) | 43.3±3.3 | 41.2±3.5 | 36.4±2.3# | 42.7±4.0* | 41.5±1.5* | 42.4±5.7* | 44.3±5.4* |
| BMP-2 (ng/mL) | 2.3±0.2 | 2.2±0.2 | 1.8±0.2## | 2.0±0.2* | 1.9±0.3 | 2.0±0.5 | 2.4±0.3** |
| BMPR-2 (ng/mL) | 1.2±0.1 | 1.1±0.1 | 0.9±0.1## | 1.1±0.1* | 1.2±0.1** | 1.2±0.1** | 1.3±0.1** |
The data were analyzed using a one-way ANOVA and expressed as means ± S.E.M. (n = 10). # P < 0.05 and ## P < 0.01 versus control mice; * P < 0.05, ** P < 0.01 and ***P < 0.001 versus osteoporosis injured mice.