Table 2. Univariate and multivariate analysis of prognostic factors of OS.

Factors	Univariate analysis			Multivariate analysis
	HR (95 % CI)	P value		HR (95 % CI)	P value
UBE2M (high vs. low)	1.871(1.020-3.433)	0.043		2.276(1.218-4.254)	0.010
TNM (III–IV vs. I–II)	4.461(2.347-8.478)	<0.001		2.966(1.409-6.243)	0.004
AFP (ng/mL) (>20 vs.≤20)	3.402(1.514-7.646)	0.003		3.309(1.313-7.034)	0.009
Tumor size (cm) (>5 vs.≤5)	2.286(1.260-4.147)	0.007		1.397(0.713-2.739)	0.330
Tumor differentiation (III–IV vs. I–II)	2.055(1.133-3.726)	0.018		1.129(0.694-2.429)	0.413
Tumor number (multiple vs. solitary)	1.194(0.645-2.211)	0.572		-	n.a.
Gender (male vs. female)	0.697(0.358-1.357)	0.288		-	n.a.
Age, years (≥ 55 vs.< 55)	0.828(0.451-1.519)	0.542		-	n.a.
HBsAg (positive vs. negative)	1.023(0.492-2.130)	0.951		-	n.a.
Cirrhosis (positive vs. negative)	1.029(0.611-2.394)	0.585		-	n.a.

n.a., not applicable.