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. 2020 Jan 27;12(3):2777–2797. doi: 10.18632/aging.102776

Table 3. RPPA analysis demonstrating the fold change in activity of proteins in response to treating MIA-PaCa-2+pLXSN cells with BBR and MBBR.

Protein name, and phosphorylation status Gene symbol Function GenBank accession no. % drop in expression
BBR MBBR
AXL receptor tyrosine kinase (AXL) AXL Promotes proliferation, stem cell phenotype AAH32229.1 34% 46%
Dynamin-related protein 1 (DRP-1) DRP-1 Promotes cell survival, migration O00429.2 44% 43%
Eukaryotic elongation factor 2 kinase (eEf2K) eEf2K Promotes cell survival, proliferation AAH32665.1 31% 38%
Glycogen synthase kinase 3α/β (GSK-3α/β_pS21_S9) GSK-3α/β Promotes cell growth & invasion NP_063937.2 92% 33%
Human epidermal growth factor receptor 2 (HER2) HER2 Correlates with worse survival P04626.1 39% 92%
Jagged canonical Notch ligand 1 (JAG1) JAG1 Promotes migration and invasion of cells NP_000205.1 38% 42%
Paired box 8 (PAX8) PAX8 Promotes cell proliferation AAB34216.1 54% 44%
Pyruvate dehydrogenase kinase 1 (PDK1) PDK1 Promotes cell growth and survival AAH39158.1 86% 35%
Ribosomal protein S6 kinase B1 (S6K1) S6K1 Promotes cell proliferation P23443.2 52% 37%
X-linked inhibitor of apoptosis (XIAP) XIAP Inhibitor of apoptosis NP_001191330.1 70% 33%