Table 3. Univariate and multivariate Cox proportional hazards regression analysis of 3-lncRNA signature and clinical risk factors in the entire dataset.

Characteristic	Univariate analysis		Multivariate analysis
	HR (95%CI)	P-Value	HR (95%CI)	P Value
Age (≥65 vs. <65)	1.585 (1.023-2.456)	0.039	1.025 (1.005-1.047)	0.016
Gender (male vs. female)	0.800 (0.532-1.205)	0.286
TNM stage (III-IV vs. I-II)	4.249 (2.143-8.424)	< 0.001	3.900 (1.962-7.752)	< 0.001
Tumor stage (T3-T4 vs. T0-T2)	2.720 (1.616-4.577)	< 0.001
Lymph node metastasis (yes vs. no)	2.455 (1.639-3.676)	< 0.001
Distant metastasis (yes vs. no)	2.321 (0.712-7.568)	0.163
Risk score (high vs. low)	2.088 (1.403-3.108)	< 0.001	1.856 (1.243-2.770)	0.002

Notes: Bold values indicate statistical significance (P<0.05).

Abbreviations: HR, hazard ratio; CI, confidence interval.