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. 2020 Feb 12;12(3):2840–2856. doi: 10.18632/aging.102781

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Copyright © 2020 Wan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The effect of uric acid on extending life span depends on its regulation of the reproductive signaling pathway. Life span analysis for (A) glp-1 (e2144) and (B) daf-12 (rh274) mutant worms when treated with 2 mM uric acid versus control (P value by log-rank test). Detailed life span values are listed in Supplementary Table 1. (C and D) The number of daily progeny and the total number of progeny of wild-type N2 worms treated with 2 mM uric acid or vehicle (means ± SD, n ≥ 30, n.s.: no significant difference, Student’s t test).