Table 3. Univariate and multivariate Cox regression analysis for predicting overall survival of ccRCC patients.

Factor	TCGA discovery set				TCGA validation set				Entire set
	Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Risk score	6.526 3.253-13.090	<0.001	3.964 1.852-8.486	<0.001	8.696 4.538-16.660	<0.001	3.957 1.727-9.067	0.001	7.714 4.799-12.400	<0.001	3.896 2.228-6.813	<0.001
Age	1.021 1.002-1.039	0.028	1.012 0.9918-1.033	0.243	1.032 1.014-1.051	<0.001	1.045 1.024-1.067	<0.001	1.027 1.014-1.040	<0.001	1.030 1.015-1.044	<0.001
Grade	2.111 1.568-2.841	<0.001	1.230 0.865-1.749	0.249	2.471 1.856-3.290	<0.001	1.368 0.995-1.881	0.054	2.267 1.846-2.785	<0.001	1.269 0.999-1.612	0.051
Stage	1.723 1.419-2.098	<0.001	1.490 1.197-1.854	<0.001	2.082 1.733- 2.500	<0.001	1.840 1.488-2.274	<0.001	1.874 1.641-2.140	<0.001	1.653 1.124-2.432	0.011
Gender (male vs female)	0.729 0.466-1.142	0.167	0.765 0.477-1.227	0.266	1.248 0.800-1.946	0.329	0.906 0.576-1.426	0.671	0.960 0.701-1.315	0.800	0.927 0.670-1.283	0.294

Bold values stand for P < 0.1.