Table 1. GO terms enrichment analysis of the deregulated genes in PG>snail-RNAi as well as hs>snail-cDNA RGs.
| #Pathway ID | Pathway description | FDR | Gene names |
|---|---|---|---|
| >2 fold down-regulated genes in PG>snail-RNAi samples | |||
| GO_biological process | Ecdysteroid biosynthetic process | 9.6E-07 | GstE14, npc1a, npc2b, dib, nvd, phm, sad, spok |
| >2 fold up-regulated genes in PG>snail-RNAi samples | |||
| GO_molecular function | Alkaline phosphatase activity/Folate biosynthesis | 5.5E-03 | Alp4, CG10592, CG3264, CG3292, CG5150, CG5361 |
| KEGG | Metabolism of xenobiotics by cytochrome P450/ Glutathione metabolism | 1.6E-03 | CG4302, CG5999, GstD2, GstD5, GstD7, GstE1, GstE10, GstE9, Ugt35b |
| InterPro domain | Protein of unknown function DUF227/CHK kinase-like | 1.0E-02 | CG10513, CG10514, CG10559, CG11892, CG11893, CG32195, CG33510, CG6834, CG9259 |
| >2 fold down-regulated genes in hs>snail-cDNA samples | |||
| Interpro domain | LPS-induced tumor necrosis factor alpha factor | 1.2E-02 | CG13510, CG13559, CG30269, CG30273, CG32280, CG42566, CG43326 |
| >2 fold up-regulated genes in hs>snail-cDNA samples | |||
| GO_biological process | Response to bacterium | 6.5E-03 | CecA1, IM14, IM23, IM4, Mtk, Sid, Yp3 |
| KEGG | Neuroactive ligand-receptor interaction | 3.2E-03 | AdoR, AstA-R2, CG30031, NPFR, deltaTry, gammaTry |
GO enrichment analysis was carried out using DAVID and STRING.
Abbreviations: FDR, false discovery rate; GO, gene ontology; hs, heat shock–induced; LPS, lipopolysaccharide; PG, prothoracic gland; RG, ring gland; RNAi, RNA interference.