. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Immunol Rev. 2019 Jul;290(1):114–126. doi: 10.1111/imr.12768

TABLE 1.

Recent major CAR-T trials in leukemia

CAR-T	Target	CR rate	Age	Tocilizumab/CRS ratio
CTL019	CD19 (4-IBB) r/r B-ALL	88/105	Pediatric	37/88
JCAR015	CD19 (CD28) r/r B-ALL	44/53	Adult	19/45
FHCRC	CD19 (4-IBB) (ALL, CLL, NHL)	31/33 (ALL only)	Adult	21/92 (from 133 total treated patients)
JCAR018	CD22 (4-IBB) r/r B-ALL	12/21	Pediatric	1/16
Axi-Cel	CD19 (CD28) Large B-cell Lymphoma	59/101	Adult	43/101

Abbreviations: ALL, acute lymphoblastic leukemia; CAR-T, chimeric antigen receptor T-cell; CR, complete remission; CRS, cytokine release syndrome; r/r, relapse/refractory.