. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Immunol Rev. 2019 Jul;290(1):114–126. doi: 10.1111/imr.12768

TABLE 3.

Modified summary of CRES/ICANS grading scales

Institution	Grade 1	Grade 2	Grade 3	Grade 4
CTCAE 5.0	Mild symptoms (brief partial seizure w/o LOC)	Symptoms limiting instrumental ADL (brief generalized seizure)	Symptoms limiting self-care ADL (multiple seizures despite medical care); New onset cerebral edema	Life threatening symptoms
CARTOX	7-9 CARTOX score (mild impairment)	3-6 CARTOX score (moderate impairment)	0-2 CARTOX score (severe impairment); seizures responsive to benzodiazepine; stage 1-2 papilledema	Critical/obtunded condition; Generalized seizures or non-convulsive status epilepticus; stage 3-5 papilledema or cerebral edema
ASBMT Adult	7-9 ICE score; awaken spontaneously	3-6 ICE score; awaken to voice	0-2 ICE score; awaken to tactile stimulus; seizure that resolves with intervention; focal edema on neuroimaging	Life threatening symptoms
ASBMT Pediatric^a	CAPD 1-8	CAPD 1-8	CAPD ≥9	Unable to perform CAPD

The CTCAE scale incorporates encephalopathy, seizure, dysphagia, tremor, headache, confusion, depressed level of consciousness and cerebral edema; CARTOX criteria incorporates Neurologic Assessment Score (CARTOX-10 score), elevated ICP, seizure or motor weakness. ASBMT criteria are based on ICE score (modified CARTOX-10 evaluation), level of consciousness, seizures, motor findings, and elevated ICP.

Abbreviations: ADL, activities of daily living; LOC, loss of consciousness.

ASBMT pediatric criteria are for children <12 and include all of the adult criteria with the addition of the CAPD score based off the Cornell delirium assessments.